Glucocorticoid receptor maps to the distal long arm of chromosome 5.
Glucocorticoid receptor maps to the distal long arm of chromosome 5.
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糖皮质激素受体定位于 5 号染色体的远端长臂。
DOI：
10.1159/000132686
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Kidd,KK
中科院分区：
文献类型：
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作者：
Giuffra,LA;Kennedy,JL;Castiglione,CM;Evans,RM;Wasmuth,JJ;Kidd,KK
类固醇激素在精神疾病中的可能作用已引起相当大的关注，糖皮质激素受体作为这些疾病异常的潜在靶点也很有意义。最近报道了一对叔侄中5 ql 1.2-* q 13.3区域的三体性易位到染色体I区段与精神分裂症有关（Bassett et al. 1988年）。以及将类葡萄糖皮质激素受体（GRL）基因座定位到该相同区域的体细胞杂交作图（Weinberger等，1985）加强了GRL在精神分裂症中的细胞学参与的假设。因此，连锁研究之间的精神分裂症和标记在这方面，包括GRL。为了在其它RFLP标记中定位GRL，我们对三个大型家系的5号染色体上的几个位点进行了连锁分析。我们的数据表明，GRL不位于近端5 q。但与D5 S22紧密连锁，D5 S22已被定位在5号染色体长臂末端附近（Leppert et al. 1987年）。
Considerable attention has been given to the possible involve ment of steroid hormones in psychiatric disorders, and the gluco corticoid receptor is of interest as a potential target for abnor malities underlying these conditions. A recent report of a trisomy of the 5ql 1.2—* q 13.3 region translocated to chromosome I seg regating with schizophrenia in an uncle-nephew pair (Bassett et al.. 1988). together with somatic cell hybrid mapping of the glucocor ticoid receptor (GRL) locus to this same region (Weinberger et al., 1985) strengthened the hypothesis of ctiologic involvement of GRL in schizophrenia. Thus, linkage studies between schizo phrenia and markers in this area, including GRL. became an ob vious research strategy.In order to localize GRL among other RFLP markers, we con ducted linkage analyses of several chromosome 5 loci in three large kindreds. Our data indicate that GRL is not located in proximal 5q. but is closely linked to D5S22 which has been mapped near the end of the long arm of chromosome 5 (Leppert et al.. 1987).