Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow
Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow
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DOI：
10.1182/blood.v88.7.2775.bloodjournal8872775
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发表时间：
1996-10-01
期刊：
影响因子：
20.3
通讯作者：
GrosseWilde, H
中科院分区：
文献类型：
--
作者：
Ottinger, HD;Beelen, DW;GrosseWilde, H
临床研究正在评估异基因外周血干细胞移植（PBSCT）相对于骨髓移植（BMT）的可能优势。在淋巴细胞亚群计数和对有丝分裂原和回忆抗原的体外增殖反应方面，我们比较了PBSCT和BMT后的免疫重建（随访：移植后5至11个月）。此外，分析了10份PBSC收获物和10份骨髓收获物的免疫活性细胞组成。与BMT患者相比，PBSCT受者的初始（CD4（+）CD45 RA（+））和记忆（CD4（+）CD45 R0（+））辅助性T细胞和B细胞（CD19（+））PB计数升高（P
Clinical studies are evaluating possible advantages of allogeneic peripheral blood stem cell transplantation (PBSCT) over bone marrow transplantation (BMT). We compared immune reconstitution after PBSCT in = 20) and BMT in = 20) in terms of lymphocyte subset counts and proliferative in vitro responses to mitogens and recall antigens (follow-up: 5 to 11 months posttransplant). Additionally, 10 PBSC harvests and 10 marrow harvests were analyzed for their composition of immunocompetent cells. Compared with BMT patients, PBSCT recipients had PB counts of naive (CD4(+)CD45RA(+)) and memory (CD4(+)CD45R0(+)) helper T cells and of B cells (CD19(+)) that were elevated (P