Acid resistant zirconium phosphate for the long term application of 68Ge/68Ga generator system
Acid resistant zirconium phosphate for the long term application of 68Ge/68Ga generator system
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DOI：
10.1016/j.apradiso.2016.09.025
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发表时间：
2016-12-01
影响因子：
1.6
通讯作者：
Kim, Sang Wook
中科院分区：
文献类型：
--
作者：
Lee, Jun Young;Vyas, Chirag K.;Kim, Sang Wook
Ge-68/Ga-68发生器系统是生产临床正电子发射断层扫描（PET）应用中即用型Ga-68的绝佳来源。吸附柱是68 Ge/68 Ga发生器系统的关键部件。因此，已经进行了几项研究，以确定在酸性洗脱液（0.1 N HCl溶液）中具有稳定和上级洗脱产率的色谱柱材料。本研究合成了四种不同的磷酸锆，其粒径为200-800 nm，孔径为55190 A，比表面积为0.72-268 m（2）g（-1）。合成并研究了无定形磷酸锆（ZrP-1），其对0.1 N HCl洗脱液具有优异的耐酸性能，比表面积达268 m2·g-1。无定形ZrP-1在0.1 N HCl洗脱液中显示出良好的Ga-68洗脱产率，为74%，同时Ge-68的穿透非常低（0.007%）。
The Ge-68/Ga-68 generator system is an excellent source for producing ready-to-use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column adsorbent is the key component for the 68Ge/68Ga generator system. Therefore, several studies have been conducted to identify column materials with a stable and superior elution yield in an acidic eluent (0.1 N HCl solution). In this study, four different zirconium phosphates were synthesized with a particle size of 200-800 nm, pore-size of 55190 A and surface area of 0.72-268 m(2) g(-1). Synthesized and studied amorphous zirconium phosphate (ZrP-1) exhibited excellent acid resistant properties for the 0.1 N HCl eluent and a large surface area of 268 m(2) g(-1). Amorphous ZrP-1 showed a good Ga-68 elution yield of 74% in 0.1 N HCl eluent accompanying extraordinary low breakthrough of Ge-68 (0.007%).