Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm.
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm.
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DOI：
10.1126/sciadv.abe3024
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发表时间：
2020-12
期刊：
影响因子：
13.6
通讯作者：
Ellebedy AH
中科院分区：
文献类型：
--
作者：
Mudd PA;Crawford JC;Turner JS;Souquette A;Reynolds D;Bender D;Bosanquet JP;Anand NJ;Striker DA;Martin RS;Boon ACM;House SL;Remy KE;Hotchkiss RS;Presti RM;O'Halloran JA;Powderly WG;Thomas PG;Ellebedy AH
免疫学评估表明，与流感患者相比，大多数 COVID-19 患者表现出靶向免疫抑制。我们对 2019 年冠状病毒病 (COVID-19) 和流感患者的免疫反应进行了研究。与流感患者相比，COVID-19 患者的淋巴细胞计数基本相同，单核细胞数量较少，并且特定单核细胞群的表面人类白细胞抗原 (HLA) II 类表达较低。此外，中间单核细胞上的 HLA-DR 减少预示着严重的 COVID-19 疾病。与普遍的假设相反，很少有（168 名）COVID-19 患者中的 7 名患者表现出细胞因子风暴综合征的细胞因子谱。在控制年龄和采样时间点等多种因素后，COVID-19 患者的细胞因子水平低于流感患者。 IL-6、G-CSF、IL-1RA 和 MCP1 的上调可预测 COVID-19 患者的死亡，但在统计学上并不高于流感患者。单细胞转录谱揭示了 COVID-19 患者干扰素信号传导的严重抑制。当从外周免疫谱的角度考虑时，COVID-19 患者的炎症程度低于流感患者。
Immunologic evaluation shows that most COVID-19 patients exhibit targeted immunosuppression compared to patients with influenza. We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)–class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional profiling revealed profound suppression of interferon signaling among patients with COVID-19. When considered across the spectrum of peripheral immune profiles, patients with COVID-19 are less inflamed than patients with influenza.
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影响因子：
5.8
作者：
Liberzon, Arthur;Subramanian, Aravind;Mesirov, Jill P.
通讯作者：
Mesirov, Jill P.
影响因子：
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作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
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Cao, Bin
影响因子：
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Shin, Eui-Cheol
DOI：
10.1186/cc8959
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kim OY;Monsel A;Bertrand M;Coriat P;Cavaillon JM;Adib-Conquy M
通讯作者：
Adib-Conquy M
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B