ASTD: The Alternative Splicing and Transcript Diversity database
ASTD: The Alternative Splicing and Transcript Diversity database
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DOI：
10.1016/j.ygeno.2008.11.003
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发表时间：
2009-03-01
期刊：
影响因子：
4.4
通讯作者：
Gautheret, Daniel
中科院分区：
文献类型：
--
作者：
Koscielny, Gautier;Le Texier, Vincent;Gautheret, Daniel
选择性剪接和转录多样性数据库（ASTD）提供了大量整合转录起始、多聚腺苷酸化和剪接变体数据的选择性转录本。替代转录本是从转录序列到完整的人类，小鼠和大鼠基因组的映射中获得的，使用的是为ASD（替代剪接数据库）和ATD（替代转录多样性）数据库开发的计算管道的扩展，这些数据库现在被ASTD取代。对于人类基因组，ASTD分别在68%、68%和62%的基因组中鉴定出剪接变异、转录起始变异和多聚腺苷酸化变异，这与目前对转录变异的估计一致。用户可以通过各种浏览和查询工具访问ASTD，包括基于表达状态的查询，以识别组织特异性异构体。参与的实验室已经通过实验验证了ASTD预测的可变剪接形式和可变多聚腺苷酸化形式的子集，这些形式以前没有报道过。美洲培发数据库可在http://www.ebi.ac.uk/astd上查阅。(C)2008年爱思唯尔公司All rights reserved.
The Alternative Splicing and Transcript Diversity database (ASTD) gives access to a vast collection of alternative transcripts that integrate transcription initiation, polyadenylation and splicing variant data. Alternative transcripts are derived from the mapping of transcribed sequences to the complete human, mouse and rat genomes using an extension of the computational pipeline developed for the ASD (Alternative Splicing Database) and ATD (Alternative Transcript Diversity) databases, which are now superseded by ASTD. For the human genome, ASTD identifies splicing variants, transcription initiation variants and polyadenylation variants in 68%, 68% and 62% of the gene set, respectively, consistent with current estimates for transcription variation. Users can access ASTD through a variety of browsing and query tools, including expression state-based queries for the identification of tissue-specific isoforms. Participating laboratories have experimentally validated a subset of ASTD-predicted alternative splice forms and alternative polyadenylation forms that were not previously reported. The ASTD database can be accessed at http://www.ebi.ac.uk/astd. (C) 2008 Elsevier Inc. All rights reserved.