Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms
Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms
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DOI：
10.1016/j.cellsig.2020.109670
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发表时间：
2020-08-01
影响因子：
4.8
通讯作者：
Rasmi, Rajan Radha
中科院分区：
文献类型：
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作者：
Dharshini, Loganathan Chandramani Priya;Vishnupriya, Selvaraj;Rasmi, Rajan Radha
氧化应激是由于活性氧（ROS）和抗氧化剂防御系统的发展失衡而导致组织损伤。导致ROS调节的一个关键问题是它改变宿主的分子、结构和功能特性，这是通过激活或抑制许多转录因子（TF）的各种信号传导途径实现的。一些调节因子包括核红细胞-2相关因子（Nrf-2）、CCAAT/增强子结合蛋白δ（CEBPD）、激活蛋白-1（AP-1）、缺氧诱导因子1（HIF-1）、核因子κ B（NF-κ B）、特异性蛋白-1（SP-1）和叉头盒O类（FoxO）转录因子。这些转录因子的表达依赖于胁迫信号，有时是相互关联的。它们是高度特异性的，有自己的调节细胞事件。根据转录因子和对氧化应激类型的更好了解，帮助研究人员开发安全的新靶点，这些靶点可以作为几种疾病的有效治疗靶点。
Oxidative stress results from the imbalances in the development of reactive oxygen species (ROS) and antioxidants defence system resulting in tissue injury. A key issue resulting in the modulation of ROS is that it alters hosts molecular, structural and functional properties which is accomplished via various signalling pathways which either activate or inhibit numerous transcription factors (TFs). Some of the regulators include Nuclear erythroid-2 related factors (Nrf-2), CCAAT/enhancer-binding protein delta (CEBPD), Activator Protein-1 (AP-1), Hypoxia-inducible factor 1 (HIF-1), Nuclear factor kappa B (NF-kappa B), Specificity Protein-1 (SP-1) and Forkhead Box class O (FoxO) transcription factors. The expression of these transcription factors are dependent upon the stress signal and are sometimes interlinked. They are highly specific having their own regulation cellular events. Depending upon the transcription factors and better knowledge on the type of the oxidative stress help researchers develop safe, novel targets which can serve as efficient therapeutic targets for several disease conditions.