Assessment of cocaine use with quantitative urinalysis and estimation of new uses.
Assessment of cocaine use with quantitative urinalysis and estimation of new uses.
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通过定量尿液分析评估可卡因使用情况并估计新用途。
DOI：
10.1111/j.1360-0443.1997.tb02938.x
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发表时间：
1997
期刊：
影响因子：
6
通讯作者：
E. J. Cone
中科院分区：
文献类型：
--
作者：
Kenzie L. Preston;Kenneth Silverman;Charles R. Schuster;E. J. Cone
监测可卡因使用的定性尿液分析方法可能过度检测使用频率，可能降低临床试验检测有效治疗的能力。作为可卡因使用的替代措施，对定量尿液分析和新制定的确定新可卡因使用的标准进行了评价。采用定性和定量方法，分析了在非寻求治疗受试者（n = 5）的可卡因给药研究和可卡因治疗试验（n = 37）中收集的尿液标本中可卡因代谢产物苯甲酰爱子碱。将药代动力学标准（“新使用”规则）应用于定量数据，以确定新使用可卡因的情况。将结果与实验室研究中已知的可卡因给药以及临床试验中受试者自我报告的药物使用和定性尿液分析进行比较。在可卡因给药研究中，除少数标本外，新使用标准正确识别了所有标本中的可卡因给药。在临床试验中，在临床试验的不同治疗条件下，定量尿分析和估计的新用途比定性尿分析提供了更多关于使用模式和频率的信息。使用新用途规则解释定量尿液分析似乎是监测治疗结果的一种有用方法，并且在估计可卡因使用频率方面可能比传统定性尿液分析更准确。
Qualitative urinalysis methods of monitoring cocaine use may over-detect frequency of use, possibly decreasing the ability of clinical trials to detect effective treatments. Quantitative urinalysis and newly developed criteria for identifying new cocaine use were evaluated as alternative measures of cocaine use. Urine specimens collected in a cocaine dosing study in non-treatment-seeking subjects (n = 5) and a cocaine treatment trial (n = 37) were analyzed for the cocaine metabolite, benzoylecgonine, with qualitative and quantitative methods. Pharmacokinetic criteria ('New Use' rules) were applied to quantitative data to identify occasions of new cocaine use. Results were compared to known cocaine administrations in the laboratory study and to self-reported drug use and qualitative urinalysis for subjects in the clinical trial. New Use criteria correctly identified cocaine administrations in the cocaine dosing study in all but a small number of specimens. In the clinical trial, quantitative urinalysis and estimated New Uses provided more information about patterns and frequency of use than qualitative urinalysis in the different treatment conditions in the clinical trial. Interpretation of quantitative urinalysis with New Use rules appears to be a useful method for monitoring treatment outcome and may be more accurate than traditional qualitative urinalysis in estimating frequency of cocaine use.
患者自我报告的药物使用情况作为治疗状态函数的有效性。
影响因子：
4.2
作者：
Sherman,MF;Bigelow,GE
通讯作者：
Bigelow,GE
氟西汀治疗美沙酮维持中的可卡因依赖：定量血浆和尿液可卡因/苯甲酰爱康宁浓度。
影响因子：
2.9
作者：
Batki,SL;Manfredi,LB;Jacob3rd,P;Jones,RT
通讯作者：
Jones,RT