Effects of sex hormones on associative learning in spontaneously hypertensive rats
Effects of sex hormones on associative learning in spontaneously hypertensive rats
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DOI：
10.1016/j.physbeh.2007.11.005
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发表时间：
2008-02-27
影响因子：
2.9
通讯作者：
Nigg, Joel T.
中科院分区：
文献类型：
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作者：
Bucci, David J.;Hopkins, Michael E.;Nigg, Joel T.
在自发性高血压大鼠（SHR）和Wistar大鼠（正常活动对照）中，研究了视觉刺激与食物配对的巴甫洛夫条件反射。自发性高血压大鼠是注意力缺陷/多动障碍（ADHD）的常用模型。在两种性腺完整的大鼠中，雄性在光线照射后花在食物杯中的时间比雌性多，这表明条件刺激（CS）与奖励的联系更强。在成年期进行的性腺切除术对两种菌株的调节影响不同。在Wistar大鼠中，性腺切除术对雌性条件反应没有影响，但减少了雄性条件反应，有效地消除了行为上的性别差异。这一结果表明，雄性Wistar大鼠体内循环的雄激素通常有助于这项任务的调节。相比之下，性腺切除术增强了SHR大鼠两性的条件作用，表明雄激素和/或雌激素损害了该品系的条件关联。这些数据表明，性腺类固醇可以影响大鼠的条件反射，并且类固醇对这种行为的效价依赖于品系。就SHR作为人类ADHD模型的程度而言，类固醇对联想学习的影响可能在ADHD样行为的表达中发挥作用。(C) 2007爱思唯尔公司版权所有。
Pavlovian conditioning of a visual stimulus paired with food was examined in spontaneously hypertensive rats (SHR), which are a commonly used model for Attention-Deficit/Hyperactivity Disorder (ADHD), and in Wistar rats (normoactive control). hi gonadally intact rats of both strains, males spent more time in the food cup following onset of the light than did females, indicating a stronger association of the conditioned stimulus (CS) with reward. Gonadectomy carried out in adulthood affected conditioning differently in the two strains. In Wistar rats, gonadectomy had no effect on conditioned responding in females, but reduced conditioned responding in males, effectively eliminating the sex difference in behavior. This result suggests that circulating androgens in male Wistar rats normally aid conditioning in this task. In contrast, gonadectomy enhanced conditioning in both sexes in the SHR rats, indicating that androgens and/or estrogens impair conditioned associations in this strain. These data indicate that gonadal steroids can influence conditioning in rats and that the valence of steroid action on this behavior is strain-dependent. To the extent that SHR serves as a model of ADHD in humans, the influence of steroids on associative learning may play a role in the expression of ADHD-like behaviors. (C) 2007 Elsevier Inc. All rights reserved.