High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in Taiwan
High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in Taiwan
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DOI：
10.1128/jcm.37.6.1829-1831.1999
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发表时间：
1999-06-01
影响因子：
9.4
通讯作者：
Liaw, YF
中科院分区：
文献类型：
--
作者：
Hsieh, SY;Wu, YH;Liaw, YF
一种新发现的DNA病毒被命名为TT病毒（TTV），被发现与输血相关性肝炎有关。我们进行了以下实验，以评估其在肝脏疾病中的致病作用和潜在的传播方式。用PCR方法检测血清中TTV DNA。13例特发性急性肝炎、14例特发性暴发性肝炎、22例慢性肝炎和19例肝硬化患者的TTV病毒血症率分别为46、64、55和63%，与50例健康对照组（53%）相比无显著性差异。来自7名肝病患者和3名健康对照的PCR产物被克隆，然后进行系统发育分析，未能将TTV强毒株与严重肝病联系起来。另外148例肝脏生化检查正常的受试者进一步评估TTV感染，包括30例新生儿（从脐带收集血清），23例婴儿，16例学龄前儿童，21例性经验之前的年龄（6至15岁），15例年轻人（年龄在30岁以下）和43例30岁以上的人。TTV病毒血症率分别为0、17、25、33、47和54%。这些研究结果表明，TTV主要通过非肠道日常接触传播，经常发生在生命的早期，TTV感染对肝脏疾病没有显着影响。
A newly identified DNA virus, named TT virus (TTV), was found to be related to transfusion-associated hepatitis. We conducted the following experiments to evaluate its pathogenic role in liver disease and potential modes of transmission. We used PCR to detect TTV DNA in serum. The rates of TTV viremia in 13 patients with idiopathic acute hepatitis, 14 patients with idiopathic fulminant hepatitis, 22 patients with chronic hepatitis, and 19 patients with cirrhosis of the liver were 46, 64, 55, and 63%, respectively, and were not significantly different from those in 50 healthy control subjects (53%), PCR products derived from seven patients with liver disease and three healthy controls were cloned and then subjected to phylogenetic analyses, which failed to link a virulent strain of TTV to severe liver disease. TTV infection was further assessed in an additional 148 subjects with normal liver biochemical tests, including 30 newborns (sera collected from the umbilical cord), 23 infants, 16 preschool children, 21 individuals of an age prior to that of sexual experience (aged 6 to 15 years), 15 young adults (aged under 30 years), and 43 individuals older than 30 years. The rates of TTV viremia were 0, 17, 25, 33, 47, and 54%, respectively. These findings suggest that TTV is transmitted mainly via nonparenteral daily contact and frequently occurs very early in life and that TTV infection does not have a significant effect on liver disease.