PURIFIED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - DIRECT ACTION ON NEUTROPHILS
PURIFIED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - DIRECT ACTION ON NEUTROPHILS
复制标题
DOI：
10.1126/science.6390681
复制
发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
GOLDE, DW
中科院分区：
文献类型：
--
作者：
GASSON, JC;WEISBART, RH;GOLDE, DW
T淋巴细胞中性粒细胞迁移抑制因子（NIF-T）是一种定位粒细胞的淋巴因子。用Mo人T淋巴母细胞系调节的培养基纯化NIF-T，一种MW为22，000的糖蛋白。NIF-T有效刺激人骨髓粒细胞和巨噬细胞集落的生长以及KG-1髓性白血病细胞系的集落形成。因此，调节成熟嗜中性粒细胞活性的人淋巴因子（NIF-T）也是作用于前体细胞以诱导新效应细胞生长和分化的集落刺激因子。
Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. Medium conditioned by the Mo human T-lymphoblast cell line was used to purify NIF-T, a glycoprotein with a MW of 22,000. The NIF-T potently stimulated the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.