RESPONDING FOR ORAL ETHANOL AFTER NALOXONE TREATMENT BY ALCOHOL-PREFERRING AA RATS
RESPONDING FOR ORAL ETHANOL AFTER NALOXONE TREATMENT BY ALCOHOL-PREFERRING AA RATS
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DOI：
10.1111/j.1530-0277.1993.tb00810.x
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发表时间：
1993-06-01
影响因子：
3.2
通讯作者：
SINCLAIR, JD
中科院分区：
文献类型：
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作者：
HYYTIA, P;SINCLAIR, JD
本研究探讨了一种相对非选择性阿片受体拮抗剂，纳洛酮，对酒精偏好的AA大鼠口服乙醇的杠杆按压的影响。的AA，不断住在可自由获取食物和水的操作室，学会了响应10%的口服乙醇在每天60分钟的酒精访问期间由刺激光指示。大鼠产生稳定的乙醇反应，导致平均乙醇摄入量为1.2 g/kg/60 min，血液中的酒精水平可测量。在第一个实验中，单次全身注射纳洛酮（0.05-2.5 mg/kg）对初始反应率没有影响;在酒精接触期间观察到剂量依赖性降低。第二个实验检查了连续5天重复注射0.5和2.5 mg/kg纳洛酮的影响。纳洛酮抑制反应的剂量相关的治疗日。与单次注射的效果相反，重复注射2.5 mg/kg纳洛酮在进入的前几分钟内产生了进行性降低。结果提示纳洛酮可减弱乙醇的增强作用。
The present study examined the effect of a relatively nonselective opioid antagonist, naloxone, on lever pressing for oral ethanol by the alcohol-preferring AA rats. The AAs, housed continually in operant chambers with free access to food and water, learned to respond for 10% oral ethanol during daily 60-min alcohol access periods indicated by a stimulus light. The rats developed stable ethanol responding, resulting in mean ethanol intakes of 1.2 g/kg/60 min and measurable blood alcohol levels. In the first experiment, single systemic injections of naloxone (0.05-2.5 mg/kg) had no effect on the initial rate of responding; dose-dependent decreases were observed later during the alcohol access. The second experiment examined the effects of repeated injections of 0.5 and 2.5 mg/kg naloxone on 5 consecutive days. Naloxone suppressed responding dose-relatedly over the treatment days. In contrast to the effects of single injections, repeated injections with 2.5 mg/kg naloxone produced progressive decreases within the first minutes of access. The results suggest that naloxone may attenuate the reinforcing actions of ethanol.