Impact of Non-Alcoholic Fatty Liver Disease on Cardiovascular Outcomes in Patients With Stable Coronary Artery Disease: A Matched Case-Control Study
Impact of Non-Alcoholic Fatty Liver Disease on Cardiovascular Outcomes in Patients With Stable Coronary Artery Disease: A Matched Case-Control Study
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DOI：
10.14309/ctg.0000000000000011
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发表时间：
2019-02-27
影响因子：
3.6
通讯作者：
Li, Jian-Jun
中科院分区：
文献类型：
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作者：
Liu, Hui-Hui;Cao, Ye-Xuan;Li, Jian-Jun
简介：非酒精性脂肪性肝病（NAFLD）是否与心血管风险相关仍存在争议。造成这种差异的原因可能与受试者选择、事件定义、NAFLD 诊断标准或研究方法有关。本研究的目的是确定患有稳定的新发冠状动脉疾病 (CAD) 的患者中 NAFLD 与心血管疾病 (CVD) 结局的关系。 方法：在 162 例病例（在平均 11,484 患者年的随访期间发生全因死亡、非致命性心肌梗塞和中风的患者）和 162 名无心血管疾病的对照组中进行了一项基于稳定的新发 CAD 队列的匹配病例对照研究。事件匹配同性别、年龄差异
INTRODUCTION: Whether non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular risk has still been controversial. The reasons for this disparity may be associated with subject selection, events definition, diagnostic criteria of NAFLD, or research methods. The aim of this study was to determine the relationship of NAFLD to cardiovascular disease (CVD) outcomes in patients with stable, new-onset coronary artery disease (CAD).METHODS: A matched case-control study based on the cohort with stable, new-onset CAD was implemented in 162 cases (patients who developed all-cause death, non-fatal myocardial infarction and stroke during an average of 11,484 patient-years of follow-up) and 162 controls without cardiovascular events matched with the same sex, the age difference