Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: Clinical case reports
Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: Clinical case reports
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DOI：
10.1111/j.1525-1594.2007.00374.x
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发表时间：
2007-04-01
影响因子：
2.4
通讯作者：
Pereira da Silva, Marcelo Cavenaghi
中科院分区：
文献类型：
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作者：
Cerruti, Humberto Filho;Kerkis, Irina;Pereira da Silva, Marcelo Cavenaghi
为了增加牙种植体必须放置的可用骨的量，本研究在32名年龄在45至75岁之间的患者中将来自骨髓穿刺液和骨支架（BS）的富血小板血浆（PRP）和单核细胞（MNCs）相关联。通过组织学、细胞培养和扫描电子显微镜证实MNC的获得和对BS的粘附。通过计算机断层扫描分析的临床结果表明，支架与皮质骨结合良好。我们可以得出结论，在患者中观察到的愈合过程是由于骨移植物中MNC组分中存在间充质干细胞。
In order to increase the amount of available bone where dental implants must be placed, the present study has associated platelet-rich plasma (PRP) and mononuclear cells (MNCs) from bone marrow aspirate and bone scaffold (BS) in 32 patients aged between 45 and 75 years old. The MNC attainment and the adherence to the BS were confirmed through histology, cell culture, and scanning electron microscopy. The clinical results, analyzed by computed tomography, have showed that the scaffolds were well integrated and adapted to the cortical bone. We can conclude that the process of healing observed in the patients was due to the presence of mesenchymal stem cell in MNC fraction in the bone grafts.