Glioma grading capability: comparisons among parameters from dynamic contrast-enhanced MRI and ADC value on DWI.
Glioma grading capability: comparisons among parameters from dynamic contrast-enhanced MRI and ADC value on DWI.
复制标题
胶质瘤分级能力：DWI上动态对比增强的MRI和ADC值的参数之间的比较。
DOI：
10.3348/kjr.2013.14.3.487
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发表时间：
2013-05
影响因子：
4.8
通讯作者：
Lee SK
中科院分区：
文献类型：
--
作者：
Choi HS;Kim AH;Ahn SS;Shin NY;Kim J;Lee SK
动态增强MRI（DCE-MRI）的渗透性参数和弥散加权成像（DWI）的表观弥散系数（ADC）值可以作为胶质瘤的定量生理指标。转移常数（Ktranss）在胶质瘤分级中显示出有效性。血管外细胞外间隙体积分数（ve）在胶质瘤分级中未得到充分利用。本研究的目的是评估ve对胶质瘤分级的能力，并评估其与其他渗透性参数和ADC值的相关性。对33例经手术病理证实的胶质瘤患者进行3 T MRI检查，包括DCE-MRI和ADC图。在肿瘤的增强实性部分上对来自DCE-MRI和ADC的渗透性参数进行感兴趣区域分析。对低级别和高级别胶质瘤之间的DCE-MRI和ADC的渗透性参数进行统计学分析;对推定指标的诊断性能和这些指标之间的相关性进行统计学分析。与低级别胶质瘤相比，高级别胶质瘤显示出更高的Ktranss（中位数为0.050 vs. 0.010，p = 0.002）和更高的ve（中位数为0.170 vs. 0.015，p = 0.001）。受试者工作特征曲线分析显示Ktranss和ve对胶质瘤分级有显著意义。然而，Ktranss和ve之间的诊断性能没有显著差异。ADC值与DCE-MRI的任何渗透性参数均不相关。血管外细胞外间隙（ve）似乎与转移常数（Ktranss）在区分高级别胶质瘤和低级别胶质瘤方面相当。ADC值与DCE-MRI的任何渗透性参数均不相关。
Permeability parameters from dynamic contrast-enhanced MRI (DCE-MRI) and apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) can be quantitative physiologic metrics for gliomas. The transfer constant (Ktrans) has shown efficacy in grading gliomas. Volume fraction of extravascular extracellular space (ve) has been underutilized to grade gliomas. The purpose of this study was to evaluate ve in its ability to grade gliomas and to assess the correlation with other permeability parameters and ADC values. A total of 33 patients diagnosed with pathologically-confirmed gliomas were examined by 3 T MRI including DCE-MRI and ADC map. A region of interest analyses for permeability parameters from DCE-MRI and ADC were performed on the enhancing solid portion of the tumors. Permeability parameters form DCE-MRI and ADC between low- and high-grade gliomas; the diagnostic performances of presumptive metrics and correlation among those metrics were statistically analyzed. High-grade gliomas showed higher Ktrans (0.050 vs. 0.010 in median value, p = 0.002) and higher ve (0.170 vs. 0.015 in median value, p = 0.001) than low-grade gliomas. Receiver operating characteristic curve analysis showed significance in both Ktrans and ve for glioma grading. However, there was no significant difference in diagnostic performance between Ktrans and ve. ADC value did not correlate with any of the permeability parameters from DCE-MRI. Extravascular extracellular space (ve) appears to be comparable with transfer constant (Ktrans) in differentiating high-grade gliomas from low-grade gliomas. ADC value does not show correlation with any permeability parameters from DCE-MRI.