The separation of processing stages in a lexical interference fMRI-paradigm
The separation of processing stages in a lexical interference fMRI-paradigm
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DOI：
10.1016/j.neuroimage.2008.10.018
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发表时间：
2009-02-01
期刊：
影响因子：
5.7
通讯作者：
Huber, Walter
中科院分区：
文献类型：
--
作者：
Abel, Stefanie;Dressel, Katharina;Huber, Walter
在图片-单词干扰范式中，图片命名过程受到语言干扰物的额外呈现的影响。与不相关的词相比，联想相关和语音相关的词会加快反应时间（RTs），而分类相关的词会减慢反应时间（RTs），因为干扰物起始发生在适当的刺激起始时间（SOAs）。在本研究中，健康的受试者，我们第一次整合所有四个courageously提出的分心类型到一个单一的范例，SOA为-200毫秒，以直接比较他们之间的行为和神经干扰效果。行为研究证实了以前的研究结果，并揭示了关联相关的干扰加快RT甚至超过语音相关的干扰，从而成为同样快的命名没有干扰。干扰物被假定为特异性地增强对应于如在单词产生的认知模型中确定的处理阶段的大脑区域的激活（Indefrey，P.，Levelt，W.J.M.，2004.词汇产生成分的空间和时间特征。Cognition 92，101-144.）.功能磁共振成像（fMRI）在3 T显示激活左侧上级颞回专门为语音相关的干扰，和激活左侧或右侧舌回专门为联想相关和分类相关的干扰，分别。此外，语音相关的干扰引起的语音-语音网络，语义干扰诱发与心理意象，语义和情景记忆检索和协会。而分心物抑制（distractor inhibition，E.例如，在一个实施例中，冲突/竞争监控）和高发音要求被观察到的类别相关的干扰，启动的发音规划揭示了联想相关的干扰。我们的结论是，激活的神经网络所获得的功能磁共振成像干扰范例可以预测从认知模型。(C)2008年爱思唯尔公司All rights reserved.
In picture-word interference paradigms, the picture naming process is influenced by an additional presentation of linguistic distractors. Naming response times (RTs) are speeded (facilitation) by associatively-related and phonologically-related words when compared to unrelated words, while they are slowed down by categorically-related words (inhibition), given that distractor onsets occur at appropriate stimulus onset asynchronies (SOAs). In the present study with healthy subjects, we for the first time integrated all four auditorily presented distractor types into a single paradigm at an SOA of -200 ms, in order to directly compare behavioral and neural interference effects between them. The behavioral study corroborated results of previous studies and revealed that associatively-related distractors speeded RTs even more than phonologically-related distractors, thereby becoming equally fast as naming without distractors. Distractors were assumed to specifically enhance activation of brain areas corresponding to processing stages as determined in a cognitive model of word production (Indefrey, P., Levelt, W.J.M., 2004. The spatial and temporal signatures of word production components. Cognition 92, 101-144.). Functional magnetic resonance imaging (fMRI) at 3 T revealed activation of left superior temporal gyrus exclusively for phonologically-related distractors, and activation of left or right lingual gyrus exclusively for associatively-related and categorically-related distractors, respectively. Moreover, phonologically-related distractors elicited phonological-phonetic networks, and both semantic distractors evoked areas associated with mental imagery, semantics, and episodic memory retrieval and associations. While processes involved in distractor inhibition (e. g., conflict/competition monitoring) and high articulatory demands were observed for categorically-related distractors, priming of articulatory planning was revealed for associatively-related distractors. We conclude that activations of neural networks as obtained by the fMRI interference paradigm can be predicted from a cognitive model. (C) 2008 Elsevier Inc. All rights reserved.