Test and diagnosis of paper-based microfluidic biochips
Test and diagnosis of paper-based microfluidic biochips
复制标题
纸基微流控生物芯片的测试和诊断
DOI：
10.1109/vts.2016.7477273
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tsung
中科院分区：
文献类型：
--
作者：
Jain;Sying;Katherine Shu;Tsung
最近，已经提出了基于纸质的微流体芯片，以实现许多应用的微流体分析。这样的芯片实现了“纸上的实验室”，而不是传统的“芯片实验室”。纸基板很有吸引力，因为它具有成本效益，易于使用和可抛置，与大多数医学/生化应用完全兼容，并且通过毛细管提供液体流动，而不会依赖外部力量和设备。多年来，研究了数字微流体（DMF）生物芯片的测试方法；但是，它们是针对传统DMF芯片开发的，因此不直接适用于纸质DMF（PB-DMF）芯片。在PB-DMF芯片中，电极是控制线在同一纸表面上打印，而电极可以用自定义结构放置。在本文中，我们提出了PB-DMF中故障的测试和诊断方法。提出了一种用于诊断性的设计方案，并显示单个故障可以通过在PB-DMF芯片中提供替代路径来找到和耐受。该方法的可行性通过实验验证。
Recently paper-based microfluidic chips have been proposed to achieve microfluidic analysis for many applications. Such chips achieve "lab-on-paper" instead of traditional "lab-on-chips". The paper substrate is attractive because it is cost-effective, easy to use and disposable, fully compatible with most medical/biochemical applications, and offering liquid flow by capillary without being relied on external forces and equipment. Test methods for digital microfluidic (DMF) biochips have been studied for years; however, they are developed for traditional DMF chips and thus are not directly applicable to paper-based DMF (PB-DMF) chips. In PB-DMF chips, electrodes are control wires are printed on the same paper surface, while electrodes can be placed with custom structure. In this paper, we present test and diagnosis methods for faults in PB-DMF. A design-for-diagnosability scheme is proposed, and it is shown that single faults can be located and tolerated by providing alternative paths in PB-DMF chips. The feasibility of the proposed method is validated through experiments.