CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems.
CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems.
复制标题
DOI：
10.3389/fncel.2014.00065
复制
发表时间：
2014
影响因子：
5.3
通讯作者：
Guyon A
中科院分区：
文献类型：
--
作者：
Guyon A
趋化因子CXCL 12/基质细胞衍生因子1 α首次在免疫系统中被描述，其功能包括淋巴细胞和巨噬细胞的趋化性、造血细胞从胎儿肝脏迁移到骨髓以及大血管的形成。在其他趋化因子中，CXCL 12最近在大脑中引起了广泛的关注，因为它不仅可以由神经胶质细胞产生，还可以由神经元产生。此外，其受体CXCR 4和CXCR 7属于G蛋白偶联受体家族，在不同的脑区域中大量表达，CXCR 4是人类免疫缺陷病毒1进入的主要共受体。这种趋化因子系统已被证明在发育过程中发生的脑可塑性过程中起重要作用，而且在正常和病理条件下的脑生理学中也起重要作用。例如，在神经元中，CXCR 4刺激已显示调节谷氨酸和γ-氨基丁酸（GABA）的突触释放。它还可以通过激活G蛋白激活的内向整流K+（GIRK），一种与神经元存活相关的电压门控K通道Kv2.1，以及通过增加高电压激活的Ca 2+电流，在突触后发挥作用。此外，最近有证据表明，CXCL 12/CXCR 4 -7系统与大脑中的其他神经递质系统（如GABA，谷氨酸，阿片类药物和大麻素）之间存在一些交叉对话。总的来说，这种趋化因子系统可能是神经免疫界面的关键参与者之一，参与塑造大脑以应对环境变化。
The chemokine CXCL12/stromal cell-derived factor 1 alpha has first been described in the immune system where it functions include chemotaxis for lymphocytes and macrophages, migration of hematopoietic cells from fetal liver to bone marrow and the formation of large blood vessels. Among other chemokines, CXCL12 has recently attracted much attention in the brain as it has been shown that it can be produced not only by glial cells but also by neurons. In addition, its receptors CXCR4 and CXCR7, which are belonging to the G protein-coupled receptors family, are abundantly expressed in diverse brain area, CXCR4 being a major co-receptor for human immunodeficiency virus 1 entry. This chemokine system has been shown to play important roles in brain plasticity processes occurring during development but also in the physiology of the brain in normal and pathological conditions. For example, in neurons, CXCR4 stimulation has been shown regulate the synaptic release of glutamate and γ-aminobutyric acid (GABA). It can also act post-synaptically by activating a G protein activated inward rectifier K+ (GIRK), a voltage-gated K channel Kv2.1 associated to neuronal survival, and by increasing high voltage activated Ca2+ currents. In addition, it has been recently evidenced that there are several cross-talks between the CXCL12/CXCR4–7 system and other neurotransmitter systems in the brain (such as GABA, glutamate, opioids, and cannabinoids). Overall, this chemokine system could be one of the key players of the neuro-immune interface that participates in shaping the brain in response to changes in the environment.
登录
查看更多内容
影响因子：
3.4
作者：
Gleichmann, M;Gillen, C;Müller, HW
通讯作者：
Müller, HW
影响因子：
3.6
作者：
Duthey, Beatrice;Huebner, Anita;Boehncke, Wolf-Henning
通讯作者：
Boehncke, Wolf-Henning
影响因子：
7.3
作者：
Benamar, Khalid;Yondorf, Menachem;Adler, Martin W.
通讯作者：
Adler, Martin W.
DOI：
10.1124/jpet.107.135053
发表时间：
2008-05-01
影响因子：
3.5
作者：
Benamar, Khalid;Geller, Ellen B.;Adler, Martin W.
通讯作者：
Adler, Martin W.
影响因子：
4
作者：
Casoni, Filippo;Hutchins, B. Ian;Wray, Susan
通讯作者：
Wray, Susan