Modular decomposition of protein-protein interaction networks.
Modular decomposition of protein-protein interaction networks.
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DOI：
10.1186/gb-2004-5-8-r57
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发表时间：
2004
期刊：
影响因子：
12.3
通讯作者：
Casari G
中科院分区：
文献类型：
--
作者：
Gagneur J;Krause R;Bouwmeester T;Casari G
This article introduces an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor necrosis factor-α (TNF-α)/NFκB transcription factor pathway.
