Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study
Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study
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DOI：
10.1186/s12199-017-0690-z
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发表时间：
2018-01-02
影响因子：
4.7
通讯作者：
Kondo, Takaaki
中科院分区：
文献类型：
--
作者：
Fujii, Ryosuke;Ueyama, Jun;Kondo, Takaaki
背景资料：人血清白蛋白（HSA）的氧化还原状态对整个身体的抗氧化特性的影响一直是最近的研究热点。HSA氧化还原状态作为减少氧化应激的生物标志物的有用性已在临床环境中进行了研究;然而，其作为非临床环境中的健康指数的重要性的证据尚未建立。本研究旨在探讨HSA氧化还原状态和颈动脉内膜中层厚度（IMT）和斑块形成的动脉粥样硬化指数之间的关联在农村population.Methods：我们进行了一项横断面研究的一部分，在农村地区的健康检查计划的北海道，日本，在2013年8月底。共有281名居民（124名男性和157名女性）被纳入最终分析。通过自我报告问卷获得生活方式相关数据，并进行超声检查以测量IMT并确定斑块形成。结果：人非巯基白蛋白和人巯基白蛋白（human mercaptalbumin，HMA）的分数与IMT呈显著负相关（标准化β =-0.132，p = 0.03）。此外，f（HMA）与斑块形成显著相关（p < 0.01），f（HMA）每增加10%，比值比为0.89（95%置信区间，0.81-0.97）。结论：我们发现，由f（HMA）确定的HSA氧化还原状态与日本受试者的动脉粥样硬化指数相关。这些结果表明，HSA的氧化还原状态表明发展动脉粥样硬化的风险。
Background: The effect of the redox state of human serum albumin (HSA) on the antioxidant properties of the entire body has been a focus of recent research. The usefulness of HSA redox state as a biomarker for reducing oxidative stress has been investigated in clinical settings; however, evidence for its significance as a health index in non-clinical settings is yet to be established. This study aimed to examine the associations between HSA redox state and the atherosclerotic indices of carotid intima-media thickness (IMT) and plaque formation in a rural Japanese population.Methods: We conducted a cross-sectional study as part of a health check-up program in the rural area of Hokkaido, Japan, at the end of August 2013. A total of 281 residents (124 men and 157 women) were included in the final analysis. Lifestyle-related data were obtained through a self-reported questionnaire, and ultrasound examinations were performed to measure IMT and determine plaque formation. The high-performance liquid chromatography postcolumn bromocresol green method was used to separate HSA into human nonmercaptalbumin and human mercaptalbumin (HMA).Results: We found a significant negative relationship between the fraction of HMA [f(HMA)] and IMT (standardized beta = -0.132, p = 0.03). Moreover, f(HMA) was significantly associated with plaque formation (p < 0.01) with an odds ratio of 0.89 (95% confidence interval, 0.81-0.97) for every 10% increment in f(HMA).Conclusions: We found that the HSA redox state, as determined by f(HMA), was associated with atherosclerotic indices in Japanese subjects. These results suggest that the HSA redox state indicates the risk of developing atherosclerosis.