The Ensembl automatic gene annotation system
The Ensembl automatic gene annotation system
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DOI：
10.1101/gr.1858004
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发表时间：
2004-05-01
期刊：
影响因子：
7
通讯作者：
Clamp, M
中科院分区：
文献类型：
--
作者：
Curwen, V;Eyras, E;Clamp, M
随着越来越多的基因组的测序，对自动的第一频繁注释的需求越来越多，这允许及时访问重要的基因组信息。 Ensembl基因构建系统可实现真核基因组的快速自动注释。它根据源自已知蛋白质，cDNA和EST序列的证据来注释基因。基因构建系统位于Core Ensembl（MySQL）数据库架构和Perl应用程序编程接口（API）之上，并且生成的数据可通过Ensembl Genome浏览器（http://wwww.ensembl.org）访问。迄今为止，Ensembl预测的基因集可用于A. gambiae，c briggsae，斑马鱼，小鼠，大鼠和人类基因组，并且在人类，小鼠，大鼠和A. gambiae基因组的出版中都非常依赖序列分析。在这里，我们详细描述了基因建设系统和所涉及的算法。从http://www.ensembl.org免费获得所有代码和数据。
As more genomes are sequenced, there is an increasing need for automated first-pass annotation which allows timely access to important genomic information. The Ensembl gene-building system enables fast automated annotation of eukaryotic genomes. It annotates genes based on evidence derived from known protein, cDNA, and EST sequences. The gene-building system rests on top of the core Ensembl (MySQL) database schema and Perl Application Programming Interface (API), and the data generated are accessible through the Ensembl genome browser (http://www.ensembl.org). To date, the Ensembl predicted gene sets are available for the A. gambiae, C briggsae, zebrafish, mouse, rat, and human genomes and have been heavily relied upon in the publication of the human, mouse, rat, and A. gambiae genome sequence analysis. Here we describe in detail the gene-building system and the algorithms involved. All code and data are freely available from http://www.ensembl.org.