IDENTIFICATION OF SELF PEPTIDES BOUND TO PURIFIED HLA-B27
IDENTIFICATION OF SELF PEPTIDES BOUND TO PURIFIED HLA-B27
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DOI：
10.1038/353326a0
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发表时间：
1991-09-26
期刊：
影响因子：
64.8
通讯作者：
WILEY, DC
中科院分区：
文献类型：
--
作者：
JARDETZKY, TS;LANE, WS;WILEY, DC
已分离出与人I类MHC分子HLA-B27结合的内源性肽库。 池和11个HPLC纯化肽的微序列分析提供了HLA-B27分子结合特异性的信息。 这些肽似乎都是九聚体，其中七个在数据库搜索中与蛋白质序列相匹配。 这些自身肽来源于丰富的胞质或核蛋白，如组蛋白、核糖体蛋白和90 K热休克蛋白家族的成员。
A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family.