Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings
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DOI：
10.1093/infdis/jiw206
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发表时间：
2017-01-01
影响因子：
6.4
通讯作者：
Zaki, Sherif R.
中科院分区：
文献类型：
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作者：
Muehlenbachs, Atis;de la Rosa Vazquez, Olimpia;Zaki, Sherif R.
在这里，我们描述临床病理特征的埃博拉病毒病在妊娠。2000年在乌干达古卢感染苏丹病毒的一名妇女死产并存活下来，2012年在刚果民主共和国伊西罗感染本迪布焦病毒的另一名妇女活产，但母婴死亡。免疫组化分析在合胞滋养细胞和胎盘母细胞单核细胞中可见埃博拉病毒抗原，胎儿胎盘间质细胞和胎儿器官中未见抗原。在Gulu病例中，埃博拉病毒抗原定位于疟原虫色素巨噬细胞。这些数据提示滋养细胞感染可能是经胎盘传播埃博拉病毒的一种机制。
Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission.