Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood.
Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood.
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DOI：
10.1002/ajmg.b.31106
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发表时间：
2010-10-05
影响因子：
2.8
通讯作者：
Everall, Ian P.
中科院分区：
文献类型：
--
作者：
Bousman, Chad A.;Chana, Gursharan;Glatt, Stephen J.;Chandler, Sharon D.;May, Todd;Lohr, James;Kremen, William S.;Tsuang, Ming T.;Everall, Ian P.
对精神障碍（例如精神分裂症）患者进行的几项基于大脑和血液的基因表达研究已将泛素蛋白酶体系统（UPS）途径中的基因确定为假定的生物标志物。然而，迄今为止，尚未在精神病症状严重程度的更广泛背景下对 UPS 通路进行检查。本研究的目的是调查阳性和阴性症状评估量表 (SAPS-SANS) 的临床评分与精神病患者血液中 UPS 通路内 43 个高度注释的基因表达之间的相关性。招募了 19 名被诊断患有精神分裂症 (n = 13) 或躁郁症 (n = 6) 的精神病患者样本。在每个选定的 UPS 基因和两个量表之间进行皮尔逊偏相关，调整性别、种族、年龄、教育、药物、吸烟和过去 6 个月的药物使用情况。 SAPS 评分与两个泛素结合基因（即 UBE2K、SIAH2）之间观察到显着的 Bonferroni 调整正相关，而与一个去泛素化基因（即 USP2）之间观察到负相关。经过多次测试校正后，没有基因表达水平与 SANS 得分显着相关。我们的研究结果表明，UPS 的失调，特别是泛素结合和去泛素化，可能表明阳性症状而非阴性症状严重程度的潜在生物学机制。
Several brain- and blood-based gene expression studies in patients with psychotic disorders (e.g., schizophrenia) have identified genes in the ubiquitin proteasome system (UPS) pathway as putative biomarkers. However, to date an examination of the UPS pathway in the broader context of symptom severity in psychosis has not been conducted. The purpose of this study was to investigate the correlation between clinical scores on the Scales for the Assessment of Positive and Negative Symptoms (SAPS–SANS) and expression of 43 highly annotated genes within the UPS pathway in blood from patients with psychosis. A sample of 19 psychotic patients diagnosed with schizophrenia (n = 13) or bipolar disorder (n = 6) were recruited. Pearson's partial correlations, adjusting for gender, ethnicity, age, education, medication, smoking, and past 6-month substance use, were performed between each of the selected UPS genes and both scales. Significant Bonferroni-adjusted positive associations were observed between SAPS scores and two ubiquitin conjugation genes (i.e., UBE2K, SIAH2), while a negative association was observed with one deubiquitination gene (i.e., USP2). No gene expression levels were significantly associated with scores on the SANS after correction for multiple testing. Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms.
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影响因子：
11.2
作者：
Ross, Owen A.;Braithwaite, Adam T.;Farrer, Matthew J.
通讯作者：
Farrer, Matthew J.
DOI：
10.1002/ajmg.b.31006
发表时间：
2010-03-05
影响因子：
2.8
作者：
Bousman, Chad A.;Chana, Gursharan;Glatt, Stephen J.;Chandler, Sharon D.;Lucero, Ginger R.;Tatro, Erick;May, Todd;Lohr, James B.;Kremen, William S.;Tsuang, Ming T.;Everall, Ian P.
通讯作者：
Everall, Ian P.
影响因子：
11
作者：
Joober, R;Benkelfat, C;Rouleau, G
通讯作者：
Rouleau, G
影响因子：
2.9
作者：
Tirat, A;Schilb, A;Filipuzzi, I
通讯作者：
Filipuzzi, I
DOI：
10.1073/pnas.170173897
发表时间：
2000-08-29
影响因子：
11.1
作者：
Lam, YA;Pickart, CM;Layfield, R
通讯作者：
Layfield, R