Detection of SARS-CoV-2 variant 501Y.V2 in Comoros Islands in January 2021.
Detection of SARS-CoV-2 variant 501Y.V2 in Comoros Islands in January 2021.
复制标题
DOI：
10.12688/wellcomeopenres.16889.1
复制
发表时间：
2021
影响因子：
--
通讯作者：
Isabella Ochola-Oyier L
中科院分区：
文献类型：
--
作者：
N Agoti C;Githinji G;S Mohammed K;W Lambisia A;R de Laurent Z;W Mburu M;M Ong'era E;M Morobe J;Otieno E;Abdou Azali H;Said Abdallah K;Diarra A;Ahmed Yahaya A;Borus P;Gumede Moeletsi N;Fred Athanasius D;Tsofa B;Bejon P;James Nokes D;Isabella Ochola-Oyier L
背景基因组数据是了解SARS-CoV-2大流行的传播和演变以及为干预措施的设计和评估提供信息的关键。然而，SARS-CoV-2基因组数据在整个非洲仍然很少，印度洋岛屿还没有报告。 方法.我们对2021年1月科摩罗联盟第一次大规模感染浪潮中的6份SARS-CoV-2阳性样本进行了基因组测序，并进行了详细的系统发育分析。 结果所有回收的6个基因组均归类为关注的501Y.V2变体（也称为谱系B.1.351），似乎来自2个亚群，最近的共同祖先日期为2020年10月30日（95%可信区间：2020年9月6日至2020年12月10日）。将科摩罗的基因组与保存在GISAID数据库中的其他国家的501Y.V2变异体的基因组进行比较，发现它们与法国和马约特岛（科摩罗群岛的一部分，法国海外省）发现的病毒密切相关。 结论.恢复的基因组，虽然很少，证实了当地传播后，可能多次引入的SARS-CoV-2 501Y.V2变异的关注在科摩罗的第一个主要COVID-19浪潮。这些发现表明了基因组监测的重要性，并对岛屿上正在进行的控制策略产生了影响。
Background. Genomic data is key in understanding the spread and evolution of SARS-CoV-2 pandemic and informing the design and evaluation of interventions. However, SARS-CoV-2 genomic data remains scarce across Africa, with no reports yet from the Indian Ocean islands. Methods. We genome sequenced six SARS-CoV-2 positive samples from the first major infection wave in the Union of Comoros in January 2021 and undertook detailed phylogenetic analysis. Results. All the recovered six genomes classified within the 501Y.V2 variant of concern (also known as lineage B.1.351) and appeared to be from 2 sub-clusters with the most recent common ancestor dated 30 th Oct-2020 (95% Credibility Interval: 06 th Sep-2020 to 10 th Dec-2020). Comparison of the Comoros genomes with those of 501Y.V2 variant of concern from other countries deposited into the GISAID database revealed their close association with viruses identified in France and Mayotte (part of the Comoros archipelago and a France, Overseas Department). Conclusions. The recovered genomes, albeit few, confirmed local transmission following probably multiple introductions of the SARS-CoV-2 501Y.V2 variant of concern during the Comoros’s first major COVID-19 wave. These findings demonstrate the importance of genomic surveillance and have implications for ongoing control strategies on the islands.