Could schizoaffective disorder, schizophrenia and bipolar I disorder be distinguishable using cognitive profiles?
Could schizoaffective disorder, schizophrenia and bipolar I disorder be distinguishable using cognitive profiles?
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DOI：
10.1016/j.psychres.2018.05.062
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发表时间：
2018-08-01
影响因子：
11.3
通讯作者：
Wang Liang-Jen
中科院分区：
文献类型：
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作者：
Chen Chih-Ken;Lee Chun-Yi;Wang Liang-Jen
本研究旨在确定分裂情感性障碍 (SAD)、精神分裂症和 I 型双相情感障碍 (BD) 患者的认知特征是否有区别。总共招募了 227 名参与者，其中包括 88 名健康对照受试者、50 名 SAD 患者、48 名精神分裂症患者和 41 名 BD 患者。使用精神分裂症认知简要评估（BAGS）评估参与者的认知功能。进行判别函数分析（DFA）以确定是否可以使用认知表现来区分这些参与者群体。与健康对照组相比，SAD、精神分裂症和双相情感障碍患者在所有认知领域（语言记忆、工作记忆、运动速度、语言流畅性、注意力和处理速度、执行功能和综合 BACS 评分）均表现出显着缺陷。在三个患者组中，精神分裂症组的运动速度受损尤其严重，BD 组在注意力、处理速度、执行功能和综合 BACS 评分方面表现最好。 DFA模型中SAD、精神分裂症和BD患者的分类准确率分别为38%、47.9%和46.3%。这些研究结果表明，BD 患者某些认知领域的损伤比精神分裂症或 SAD 患者的严重程度要轻。
This study seeks to determine whether the cognition profiles of patients with schizoaffective disorder (SAD), schizophrenia and bipolar I disorder (BD) are distinguishable. A total of 227 participants, comprising 88 healthy control subjects, 50 patients with SAD, 48 patients with schizophrenia and 41 patients with BD, were recruited. The participants' cognitive functions were evaluated using the Brief Assessment of Cognition in Schizophrenia (BAGS). A discriminant functions analysis (DFA) was conducted to determine whether using cognitive performance can be used to distinguish these participant groups. Relative to healthy control subjects, patients with SAD, schizophrenia and BD exhibited significant deficits in all cognitive domains (verbal memory, working memory, motor speed, verbal fluency, attention and processing speed, executive function and a composite BACS score). Among the three patient groups, the schizophrenia group exhibited particularly impaired motor speed, and the BD group performed best in attention, processing speed, executive function and the composite BACS score. The classification accuracy rates of patients with SAD, schizophrenia and BD in the DFA model were 38%, 47.9% and 46.3%, respectively. These findings suggest that the impairments of some cognitive domains were less severe in patients with BD than in patients with schizophrenia or SAD.