Free fatty acids and insulin secretion in humans.
Free fatty acids and insulin secretion in humans.
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DOI：
10.1007/s11892-005-0004-5
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发表时间：
2005-06-01
影响因子：
4.2
通讯作者：
Boden, Guenther
中科院分区：
文献类型：
--
作者：
Boden, Guenther
长链脂肪酸血浆水平的急性增加通过刺激胰岛素分泌或通过降低胰岛素清除率来提高血浆胰岛素水平。在正常受试者中，脂肪酸的长期升高也刺激胰岛素分泌。事实上，它们精确地增加胰岛素到补偿脂肪酸诱导的胰岛素抵抗所需的程度。相反，在遗传上易患2型糖尿病的个体（前驱糖尿病受试者）中，游离脂肪酸（FFA）刺激胰岛素分泌不足以完全补偿FFA诱导的胰岛素抵抗。因此，肥胖，如果与脂肪酸水平升高，可能会导致糖尿病前期高血糖症，但不是在正常人。
Acute increases in plasma levels of long-chain fatty acids raise plasma insulin levels by stimulating insulin secretion or by decreasing insulin clearance. In normal subjects, long-term elevations of fatty acids also stimulate insulin secretion. In fact, they increase insulin precisely to the degree needed to compensate for the fatty acid-induced insulin resistance. In contrast, in individuals who are genetically predisposed to develop type 2 diabetes (prediabetic subjects), the free fatty acid (FFA) stimulation of insulin secretion is not sufficient to fully compensate for the FFA-induced insulin resistance. Therefore, obesity, if associated with elevated fatty acid levels, may lead to hyperglycemia in prediabetic but not in normal individuals.