A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important
A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important
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DOI：
10.1111/pcmr.12035
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Anton-Culver, Hoda
中科院分区：
文献类型：
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作者：
Liu, Feng;Bessonova, Leona;Anton-Culver, Hoda
使用美国 SEER17 注册数据，计算了特定年龄的黑色素瘤发病率，并对男性和女性进行了比较。计算每个年龄组男性和女性的相对风险 (RR)，并与北欧癌症登记数据集和非黑色素瘤皮肤癌 (NMSC) 的相对风险进行比较。对于 44 岁及以下年龄组，女性的发病率较高，差异峰值出现在 20-24 岁之间（RR = 2.01，95% CI = 1.21-3.33）。男性在 44 岁后表现出更高的发病率。北欧癌症登记数据集证实了相同的双峰性别差异，但在 NMSC 中没有观察到这种差异，众所周知，NMSC 与累积暴露于太阳紫外线辐射密切相关。我们得出的结论是，暴露于太阳紫外线 (UV) 辐射是老年（>44 岁）黑色素瘤的主要致病因素，但其他因素也可能在早发黑色素瘤中发挥作用，特别是在女性中。
Using US SEER17 Registry data, age-specific melanoma incidence rates were calculated and comparisons were made between males and females. Relative Risk (RR) for males and females in each age group was computed and compared with that from Nordic Cancer Registry data set and to that for non-melanoma skin cancer (NMSC). For age groups 44 and younger, females showed higher incidence rates, with a peak difference at age 20-24 (RR = 2.01, 95% CI = 1.21-3.33). Males exhibited higher incidence rates after age 44. The same bimodal gender difference was confirmed by the Nordic Cancer Registry data set, but it was not observed for NMSC, which is known to be strongly associated with cumulative exposure to solar UV radiation. We conclude that exposure to solar ultraviolet (UV) radiation is the major causative factor for melanoma at older age (>44 yr), but that other factors may play a role in early onset melanomas, particularly in females.