Reconstruction of mastoid cortex defect using bone morphogenetic protein: An experimental study in the guinea pig
Reconstruction of mastoid cortex defect using bone morphogenetic protein: An experimental study in the guinea pig
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DOI：
10.1080/00016480410016234
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发表时间：
2004-03-01
影响因子：
1.4
通讯作者：
Gyo, K
中科院分区：
文献类型：
--
作者：
Sugimoto, A;Hakuba, N;Gyo, K
目的：观察重组人骨形态发生蛋白-2（rhBMP-2）在豚鼠颞骨内的成骨作用。方法：在颞骨中央钻一个直径为4 mm的孔，用rhBMP-2浸润胶原膜，在骨内植入一个小的骨缺损区。2、放在洞里。通过X线检查确认新骨形成，并使用双能X线吸收测定法1定量骨矿物质密度，结果rhBMP-2治疗组的骨密度明显高于对照组。结论rhBMP-2治疗组的骨密度明显高于对照组。2诱导颞骨新骨形成，在临床耳部手术中有一定的应用价值。
Objective - The aim of this experimental study was to examine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) could induce new bone formation in a small hole drilled through the temporal bone near the external auditory canal wall in guinea pigs.Material and Methods - A 4-mm diameter hole was made in the center of the temporal bone and a piece of collagen sheet infiltrated with rhBMP-2 was placed in the hole. New bone formation was confirmed by means of X-ray examination and the bone mineral density was quantified using dual-energy X-ray absorptiometry 1, 2 and 4 weeks after treatment.Results - The bone mineral density in the rhBMP-2-treated group was significantly increased compared to the control group.Conclusion - These results suggest that rhBMP-2 induces remarkable new bone formation in the temporal bone and will be useful in clinical ear surgery.