Antihyperglycemic activity of chalcone based novel 1-{3-[3-(substituted phenyl) prop-2-enoyl] phenyl} thioureas
Antihyperglycemic activity of chalcone based novel 1-{3-[3-(substituted phenyl) prop-2-enoyl] phenyl} thioureas
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DOI：
10.1080/00397911.2018.1539178
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发表时间：
2018-12-02
影响因子：
2.1
通讯作者：
Mondal, Arijit
中科院分区：
文献类型：
--
作者：
Acharjee, Satarupa;Maity, Tapan Kumar;Mondal, Arijit
本研究利用Claisen Schmidt缩合反应合成了新型查尔酮基硫脲类化合物1-{3-[3-(取代苯基)丙基-2-烯基]苯基}硫脲(4a-c)，并研究了它们在糖尿病和氧化应激反应中的保护作用。研究了合成化合物的光谱性质。在一项为期6周的研究中，化合物4b对链脲佐菌素(STZ)诱导的糖尿病大鼠的降糖作用进行了筛选，发现化合物4b具有显著的降糖作用(p
The present study describes the synthesis of novel chalcone based 1-{3-[3-(substituted phenyl) prop-2-enoyl] phenyl} thioureas (4a-c) using Claisen Schmidt condensation and investigates their protective role in diabetic conditions and associated oxidative stress. Spectral properties for the synthesized compounds were studied. Novel compounds were screened for antihyperglycemic effect in streptozotocin (STZ)-induced diabetic rats in a 6 week study and compound 4b exhibited significant (p