The metal site as a template for the metalloprotein structure formation
The metal site as a template for the metalloprotein structure formation
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DOI：
10.1016/s0162-0134(01)00337-3
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发表时间：
2002-01-01
影响因子：
3.9
通讯作者：
Xu, HB
中科院分区：
文献类型：
--
作者：
Liu, CL;Xu, HB
彻底解释金属位点在天然金属蛋白结构形成中的行为是金属生物大分子生物化学中令人兴奋的挑战。这项研究提出了对该主题的个人见解。提出金属中心及其外源配体构成模板。模板可以对松散的肽链施加明确的立体化学偏好，并通过金属-配体相互作用（长程强相互作用）将它们组织成自然的立体特异性。因此，模板多面体周围的模板效应诱导的稳定肽构象可以称为模板介导的结构基序（TMSM）。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Achieving a thorough explanation of the behavior of metal sites in the formation of native metalloprotein structures is an exciting challenge in the biochemistry of metallobiomacromolecules. This study presents a personal insight into the subject. It is proposed that a metal center and its exogenous ligand compose a template. A template may impose a clear stereochemical preference on the loose peptide chains, and organize them into natural stereospecificity via the metal-ligand interaction, a long-range and strong interaction. Therefore, the stable peptide conformation induced by the template effect surrounding a template polyhedron could be called a template-mediated structural motif (TMSM). (C) 2002 Elsevier Science B.V. All rights reserved.