New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana
New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana
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土茯苓根茎中具有抗炎和细胞毒活性的新型呋甾烷皂苷
DOI：
10.1016/j.steroids.2017.08.013
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发表时间：
2017-11-01
期刊：
影响因子：
2.7
通讯作者：
Huang, Huilian
中科院分区：
文献类型：
--
作者：
Zhou, Meng;Huang, Liping;Huang, Huilian
从刺菝葜根茎中分得七个新的呋甾皂苷。通过2D NMR光谱技术（H-1，H-1-COSY，NOESY，HSQC和HMBC），质谱和文献比较确定了它们的结构。对分离得到的化合物进行了体外抗炎和细胞毒活性评价。发现化合物3、5和7通过抑制IL-1 β产生并促进LPS刺激的RAW 264.7细胞中IL-10的表达而具有适度的抗炎作用。Davidianoside F（6）分别在10.2 μ M和4.31.mu M的浓度下显示出抗MCF-7和HELA细胞系的活性。
Seven new furostanol saponins have been isolated from the rhizomes of Smilax davidiana. Their structures were established by 2D NMR spectroscopic techniques (H-1,H-1-COSY, NOESY, HSQC and HMBC), mass spectrometry and comparison with the literature. The isolated compounds were subjected to evaluate anti-inflammatory and cytotoxic activities in vitro. Compounds 3, 5 and 7 were found to have modest anti-inflammatory effects through suppression of IL-1 beta production and promote the expression of IL-10 in LPS-stimulated RAW 264.7 cells. Davidianoside F (6) showed activity against MCF-7 and HELA cell lines at the concentration of 10.2 mu M and 4.31.mu M, respectively.