CELLS THAT RESORB BONE
CELLS THAT RESORB BONE
复制标题
DOI：
10.1056/nejm198402163100709
复制
发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
COCCIA P F
中科院分区：
文献类型：
--
作者：
COCCIA P F
骨重建是一个持续的骨基质合成和骨吸收的过程，受多种激素和其他因素的调节。骨形成及其调节最近已在Journal. 1中进行了综述。骨吸收不仅是骨骼生长和重塑所必需的，而且也是调节血清钙和磷酸盐浓度所必需的，它受到甲状旁腺激素、1，25-二羟维生素D3（骨化三醇）、前列腺素E2和淋巴因子破骨细胞活化因子的刺激。它被降钙素和二膦酸盐化合物和光辉霉素抑制。过度的骨吸收发生在各种系统性…
Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in theJournal.1Bone resorption, which is necessary not only for skeletal growth and remodeling but also for the regulation of serum calcium and phosphate concentrations, is stimulated by parathyroid hormone, 1,25-dihydroxyvitamin D3(calcitriol), prostaglandin E2, and the lymphokine osteoclast-activating factor. It is inhibited by calcitonin and by diphosphonate compounds and mithramycin. Excessive bone resorption occurs in a variety of systemic . . .