B16-MURINE MELANOMA AND AGING - SLOWER GROWTH AND LONGER SURVIVAL IN OLD MICE
B16-MURINE MELANOMA AND AGING - SLOWER GROWTH AND LONGER SURVIVAL IN OLD MICE
复制标题
DOI：
10.1093/jnci/72.1.161
复制
发表时间：
1984-01-01
影响因子：
10.3
通讯作者：
TINDLE, BH
中科院分区：
文献类型：
--
作者：
ERSHLER, WB;STEWART, JA;TINDLE, BH
研究了幼龄(3mo)和老龄(24mo)C57BL/6小鼠体内移植黑色素瘤的生长特性和定植潜能。皮下注射B16-F10黑色素瘤细胞后，老龄小鼠肿瘤生长较慢，最终肿瘤体积较小。此外，静脉注射B16-F1黑色素瘤细胞后，肺内克隆数也较少，老年小鼠的存活率较高。这些发现表明，在这个实验性肿瘤模型中，年龄优势可能归因于物理或免疫因素。
The growth characteristics and colonization potential of a transplantable melanoma administered to young (3 mo) and old (24 mo) C57BL/6 mice were investigated. After sc injection of B16-F10 melanoma cells, tumor growth was slower, and final tumor volume was less in the older mice. Furthermore, after iv injection of B16-F1 melanoma cells, the number of pulmonary colonies was also less, and the survival was greater in the older mice. These findings indicate an age advantage in this experimental tumor model that may be attributed to either physical or immunologic factors.