Nitric oxide, platelet function, myocardial infarction and reperfusion therapies
Nitric oxide, platelet function, myocardial infarction and reperfusion therapies
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DOI：
10.1023/a:1022194921040
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发表时间：
2003-01-01
影响因子：
4.6
通讯作者：
Radomski, MW
中科院分区：
文献类型：
--
作者：
Alonso, D;Radomski, MW
血小板在生理性止血和病理性血栓形成中发挥着重要作用，后者使血管疾病的过程复杂化。血小板的许多功能，包括黏附、聚集和募集，是由血小板和内皮细胞产生的一氧化氮(NO)控制的。这一代人的紊乱可能参与了血管疾病血栓并发症的发病机制。用释放NO的药物对病变血管系统进行药物补充，可能有助于恢复止血平衡。
Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.