Reentry Near the Percolation Threshold in a Heterogeneous Discrete Model for Cardiac Tissue
Reentry Near the Percolation Threshold in a Heterogeneous Discrete Model for Cardiac Tissue
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DOI：
10.1103/physrevlett.110.158101
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发表时间：
2013-04-09
影响因子：
8.6
通讯作者：
Baer, Markus
中科院分区：
文献类型：
--
作者：
Alonso, Sergio;Baer, Markus
心脏组织中的心律失常与心脏中的不规则电波传播有关。心脏组织由离散的细胞网络形成，其通常是异质的。局部区域有一部分非传导性连接被均匀的传导组织包围，可能成为折返和异位搏动的来源。在心脏组织的离散模型中的广泛模拟表明，穿过心脏组织的异质区域的波可以分解成不规则的图案，只要非导电链接的分数接近细胞网络的渗透阈值。这个分数，系统的大小，和程度的兴奋性的再入概率的依赖关系可以推断出非导电簇的尺寸分布附近的逾渗阈值。DOI：10.1103/PhysRevLett.110.158101
Arrhythmias in cardiac tissue are related to irregular electrical wave propagation in the heart. Cardiac tissue is formed by a discrete cell network, which is often heterogeneous. A localized region with a fraction of nonconducting links surrounded by homogeneous conducting tissue can become a source of reentry and ectopic beats. Extensive simulations in a discrete model of cardiac tissue show that a wave crossing a heterogeneous region of cardiac tissue can disintegrate into irregular patterns, provided the fraction of nonconducting links is close to the percolation threshold of the cell network. The dependence of the reentry probability on this fraction, the system size, and the degree of excitability can be inferred from the size distribution of nonconducting clusters near the percolation threshold. DOI: 10.1103/PhysRevLett.110.158101