INFLUENCE OF L-DOPA ON TRANSMISSION IN LONG ASCENDING PROPRIOSPINAL PATHWAYS IN CAT
INFLUENCE OF L-DOPA ON TRANSMISSION IN LONG ASCENDING PROPRIOSPINAL PATHWAYS IN CAT
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DOI：
10.1016/0006-8993(73)90625-2
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发表时间：
1973-01-01
期刊：
影响因子：
2.9
通讯作者：
REITSMA, DJ
中科院分区：
文献类型：
--
作者：
BERGMANS, J;MILLER, S;REITSMA, DJ
在高位脊髓猫中，研究了静脉注射1 - 3，4-二羟基苯丙氨酸（DOPA）对长的上行脊髓本体通路向某些前肢运动神经元群的传递的影响。早期放电诱发的胸大肌和深桡运动神经元的后肢传入，这可能是在一些高脊柱准备电刺激后，促进多巴。多巴后，同一前肢运动神经元出现迟发放电（30-80毫秒），通常可持续600毫秒或更长。前肢单突触反射和多突触反射的后肢神经促进作用也同样延长。同侧后肢神经比对侧更有效。晚放电也引起前肢运动神经元刺激前肢传入后多巴和它的结论是，晚反射的组织存在于臂段以前报道的Jankowskaet al.in腰cord.The影响多巴长上行propriospinal和前肢反射归因于兴奋的终端去甲肾上腺素能网状脊髓纤维。这种反射的变化反映了猫控制踏步的神经元系统的活动。刺激C1脊髓腹侧象限可以激发另一个系统，改变长的上行脊髓本体传递。对脊髓本体传递的影响可能比刺激持续几十分钟。
In high spinal cats the influence of an intravenous injection ofl-3,4,-dihydroxyphenylalanine (DOPA) has been investigated on the transmission of long ascending propriospinal pathways to certain groups of forelimb motoneurones. The early discharge evoked in pectoralis major and deep radial motoneurones on electrical stimulation of hindlimb afferents, which may be obtained in some high spinal preparations, is facilitated after DOPA. A late discharge (30–80 msec) appears after DOPA in the same forelimb motoneurones and may often last up to 600 msec or more. Facilitation by hindlimb nerves of forelimb mono- and polysynaptic reflexes is similarly prolonged. Ipsilateral hindlimb nerves are more effective than contralateral. Late discharges have also been evoked in forelimb motoneurones on stimulation of forelimb afferents after DOPA and it is concluded that a somewhat similar organization of late reflexes exists in brachial segments as previously reported by Jankowskaet al.in the lumbar cord.The influence of DOPA on long ascending propriospinal and forelimb reflexes is ascribed to excitation of the terminals of noradrenergic reticulospinal fibres. The reflex changes are considered to reflect activity in neuronal systems involved in the control of stepping in the cat.A further system modifying long ascending propriospinal transmission could be excited by stimulation of the ventral quadrant of the spinal cord at C1. The effects on propriospinal transmission could outlast the stimulus by several tens of minutes.