Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β-cells
Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β-cells
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DOI：
10.2337/diabetes.54.8.2396
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发表时间：
2005-08-01
期刊：
影响因子：
7.7
通讯作者：
Mathieu, C
中科院分区：
文献类型：
--
作者：
Gysemans, CA;Ladrière, L;Mathieu, C
免疫攻击下的β细胞通过细胞内关键信号级联的异常激活而被破坏。本研究的目的是通过研究STAT-1基因敲除(-/-)小鼠的β细胞对免疫介导的细胞死亡的敏感性，来评价信号转导和转录激活因子-1(STAT-1)途径在R细胞凋亡中的作用。STAT-1(-/-)小鼠的整个胰岛对干扰素(干扰素)-γ(结合白介素[IL]-1β)介导的细胞死亡完全抵抗(STAT-1(-/-)小鼠92+/-4%的活细胞，而野生型对照组为56+/-3%，P
beta-Cells under immune attack are destroyed by the aberrant activation of key intracellular signaling cascades. The aim of the present study was to evaluate the contribution of the signal transducer and activator of transcription (STAT)-1 pathway for R-cell apoptosis by studying the sensitivity of beta-cells from STAT-1 knockout (-/-) mice to immune-mediated cell death in vitro and in vivo. Whole islets from STAT-1(-/-) mice were completely resistant to interferon (IFN)-gamma (studied in combination with interleukin [IL]-1 beta)-mediated cell death (92 +/- 4 % viable cells in STAT-1(-/-) mice vs. 56 +/- 3 % viable cells in wild-type controls, P