From high-throughput to therapeutic: host-directed interventions against influenza viruses.
From high-throughput to therapeutic: host-directed interventions against influenza viruses.
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DOI：
10.1016/j.coviro.2021.12.014
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发表时间：
2022-04
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
流感病毒同时受到宿主细胞内因素的支持和拮抗。这种密切的关系是未来针对宿主而不是病毒本身的抗病毒药物的理论基础，这一概念被称为宿主导向疗法。基因筛查已导致识别能够调节流感病毒感染的宿主因素，这些因素是宿主导向抗病毒策略的候选靶点。然而，尽管在理解宿主靶标方面取得了进展，但目前还没有针对临床使用的针对宿主的流感病毒干预措施。在这篇简短的综述中，我们讨论了在基因敲除/基因敲除和过度表达筛查中确定的一些宿主因素，这些因素可能被作为宿主指导的流感干预策略的目标。我们进一步评论了利用RNA递送载体和瞬时CRISPR介导的基因打靶改变呼吸道基因表达的可行性。
Influenza viruses are simultaneously supported and antagonized by factors within the host cell. This close relationship is the theoretical basis for future antivirals that target the host rather than the virus itself, a concept termed host-directed therapeutics. Genetic screening has led to the identification of host factors capable of modulating influenza virus infections, and these factors represent candidate targets for host-directed antiviral strategies. Despite advances in understanding host targets however, there are currently no host-directed interventions for influenza viruses in clinical use. In this brief review, we discuss some host factors identified in knockout/knockdown and overexpression screens that could potentially be targeted as host-directed influenza intervention strategies. We further comment on the feasibility of changing gene expression in the respiratory tract with RNA delivery vectors and transient CRISPR-mediated gene targeting.
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