Idiopathic thrombocytopenic purpura in the older adult patient.
Idiopathic thrombocytopenic purpura in the older adult patient.
复制标题
老年患者特发性血小板减少性紫癜。
DOI：
--
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
L. Prisant
中科院分区：
文献类型：
--
作者：
T. Guthrie;Donald P. Brannan;L. Prisant
从1954年3月至1983年12月，在格鲁吉亚医学院，我们观察了40例年龄在45岁以上的特发性血小板减少性紫癜（ITP）成人。所有患者就诊时均有出血表现。随访期间，40例患者中有21例（52.5%）发生危及生命或致死性出血事件。与未达到完全缓解的患者相比，达到完全缓解的患者的任何临床或实验室特征均无显著差异。对治疗的完全反应、较年轻、较高的血红蛋白水平和无中枢神经系统出血对总生存率有有利影响。治疗在这个年龄组是无效的，只有12名患者（30%）达到永久完全缓解。14名患者（35%）死于出血或治疗的直接并发症。这项对老年人ITP的分析表明，这种疾病对治疗难治，与严重的发病率和死亡率相关。
Forty adults with idiopathic thrombocytopenic purpura (ITP), aged over 45 years, were seen from March 1954 to December 1983 at the Medical College of Georgia. All patients had bleeding manifestations at presentation. Twenty-one of 40 (52.5%) during the follow-up period had either life-threatening or fatal bleeding episodes. There were no significant differences for the presence of any presenting clinical or laboratory feature for patients who achieved a complete remission compared with those who did not. A complete response to therapy, younger age, higher presenting hemoglobin level, and absence of central nervous system bleeding favorably influenced overall survival. Therapy was ineffective in this age group, with only 12 patients (30%) achieving a permanent complete remission. Fourteen patients (35%) died either from bleeding or from direct complications of therapy. This analysis of ITP in the older adult suggests a disease refractory to therapy that is associated with major morbidity and mortality.