Incorporation of methylene blue and nanogold into polyvinyl chloride catheters; a new approach for light-activated disinfection of surfaces
Incorporation of methylene blue and nanogold into polyvinyl chloride catheters; a new approach for light-activated disinfection of surfaces
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DOI：
10.1039/c2jm31987j
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Parkin, Ivan P.
中科院分区：
文献类型：
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作者：
Noimark, Sacha;Dunnill, Charles W.;Parkin, Ivan P.
通过使用丙酮-水混合物的简单"溶胀-封装-收缩"方法，将亚甲蓝和2 nm金纳米颗粒掺入商业PVC导管中。无论是亚甲基蓝，也没有纳米金浸出到水溶液中，组装是稳定的激光照射后的光降解。将改良导管暴露于红色激光4 - 8分钟诱导表皮葡萄球菌和大肠杆菌的致死性光敏化。从时间分辨EPR光谱的结果表明，增强亚甲蓝三重态生产发生在2 nm的金纳米粒子的存在下。这意味着活性氧物质的水平在这些共掺杂的材料中比单独使用亚甲基蓝时更高。
Methylene blue and 2 nm gold nanoparticles were incorporated into commercial PVC catheters by use of a simple "swell-encapsulation-shrink'' method using acetone-water mixtures. Neither the methylene blue nor the nanogold leached into aqueous solution and the assemblage was stable to photodegradation upon laser irradiation. Exposure of the modified catheters to red laser light for 4-8 minutes induced the lethal photosensitisation of Staphylococcus epidermidis and Escherichia coli. Results from time-resolved EPR spectroscopy suggested that enhanced methylene blue triplet state production occurs in the presence of 2 nm gold nanoparticles. The implication being that the levels of reactive oxygen species are higher in these co-doped materials than with methylene blue alone.