A novel application of four-dimensional magnetic resonance angiography using an arterial spin labeling technique for noninvasive diagnosis of Moyamoya disease
A novel application of four-dimensional magnetic resonance angiography using an arterial spin labeling technique for noninvasive diagnosis of Moyamoya disease
复制标题
DOI：
10.1016/j.clineuro.2015.07.003
复制
发表时间：
2015-10-01
影响因子：
1.9
通讯作者：
Houkin, Kiyohiro
中科院分区：
文献类型：
--
作者：
Uchino, Haruto;Ito, Masaki;Houkin, Kiyohiro
背景资料：使用动脉自旋标记技术（ASL-4D MRA）的非对比增强时间分辨四维磁共振血管造影术正在成为治疗神经血管疾病的下一代血管造影术。本研究以数字减影血管造影（DSA）和飞行时间MRA（TOF MRA）为标准，评价ASL-4D MRA诊断烟雾病（Moyamoya disease，MMD）的可行性及MMD分期。两名独立观察员评估了这三项测试。对数据进行分析，以获得观察者之间和MMD阶段的模态间一致性。22个半球中的9个接受了手术血运重建，ASL-4D MRA在术后重复检查。结果：所有22个非手术半球均可见时间分辨的血液流入脑血管，包括烟雾血管。DSA和ASL-4DMRA对18个半球MMD分期完全一致，两者之间存在显著正相关（r=0.93，P
Background: Noncontrast-enhanced time-resolved four-dimensional magnetic resonance angiography using an arterial spin labeling technique (ASL-4D MRA) is emerging as a next generation angiography for the management of neurovascular diseases. This study evaluated the feasibility of ASL-4D MRA for the diagnosis of Moyamoya disease (MMD) and MMD staging by using digital subtraction angiography (DSA) and time-of-flight MRA (TOF MRA) as current standards.Methods: Eleven consecutive non-operated patients who underwent DSA for the diagnosis of MMD were recruited. Two independent observers evaluated the three tests. The data were analyzed for inter-observer and inter-modality agreements on MMD stage. Nine of 22 hemispheres underwent surgical revascularization and ASL-4D MRA was repeated postoperatively.Results: Time-resolved inflow of blood through the cerebral vessels, including moyamoya vessels, was visualized in all the 22 non-operated hemispheres. MMD stages assessed by DSA and ASL-4D MRA were completely matched in 18 hemispheres, with a significant positive correlation between these modalities (r=0.93, P