Mesenchymal stem cells
Mesenchymal stem cells
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DOI：
10.1136/thoraxjnl-2012-201923
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发表时间：
2012-05
期刊：
影响因子：
10
通讯作者：
S. Rankin
中科院分区：
文献类型：
--
作者：
S. Rankin
间充质干细胞 (MSC) 是一种基质细胞，可以很容易地从成人骨髓和脂肪组织以及脐带中采集。对于呼吸道疾病，这些细胞的治疗潜力在于它们的旁分泌作用，这是它们增强组织再生和调节免疫反应的能力的基础。间充质干细胞已被证明在一系列呼吸道疾病小鼠模型中有效，目前有五项临床试验涉及使用间充质干细胞治疗呼吸道疾病，包括慢性阻塞性肺病和肺气肿。本文总结了MSCs的特点。
Mesenchymal Stem cells (MSCs) are stromal cells that can be readily harvested from adult bone marrow and adipose tissue, but also umbilical cords. With respect to respiratory disease, the therapeutic potential of these cells lies in their paracrine effects which underlie their ability to enhance tissue regeneration and modulate immune responses. MSCs have been shown to be effective in a range of murine models of respiratory disease, and there are currently five clinical trials involving the administration of MSCs for respiratory diseases, including COPD and emphysema. This paper summarises the features of MSCs.