TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway
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TRPM7通过MAPK通路介导乳腺癌细胞迁移和侵袭
DOI：
10.1016/j.canlet.2013.01.031
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发表时间：
2013-06-01
期刊：
影响因子：
9.7
通讯作者：
Zou, Fei
中科院分区：
文献类型：
--
作者：
Meng, Xiaojing;Cai, Chunqing;Zou, Fei
转移是乳腺癌的固有特征，并且发现瞬时受体电位（TRP）通道可能与此过程有关。特别地，TRPM 7可以调节细胞运动性。因此，我们检查了Oncomine数据库中TRPM 7 mRNA的表达，发现TRPM 7与转移和浸润性乳腺癌相关。用RNA干扰沉默TRPM 7导致MDA-MB-435乳腺癌细胞的迁移和侵袭能力显著降低，Src和MAPK的磷酸化水平显著降低，但AKT没有降低。我们的研究结果表明，TRPM 7通过MAPK途径调节转移性乳腺癌细胞的迁移和侵袭。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.