Bone mineral density in children with cerebral palsy
Bone mineral density in children with cerebral palsy
复制标题
DOI：
10.1046/j.1442-200x.2001.01352.x
复制
发表时间：
2001-04-01
影响因子：
1.4
通讯作者：
Karakelleoglu, C
中科院分区：
文献类型：
--
作者：
Tasdemir, HA;Buyukavci, M;Karakelleoglu, C
方法：对24例脑性瘫痪(CP)患儿进行骨密度(BMD)、钙(Ca)、磷(P)、碱性磷酸酶(ALP)、肌酐(Scr)、甲状旁腺激素(PTH)和25-羟基维生素D-3(25OHD(3))测定。结果：患者组的调整后平均骨密度值低于对照组(P<；0.05)。而非流动酸中毒患儿骨密度值无明显变化，而钙、磷水平显著高于对照组(P<；0.05)。结论：本研究显示所有CP患儿骨密度均有下降，但非流动酸中毒患儿BMD下降幅度更大，制动是影响骨矿化的主要因素。
Background: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP).Methods: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D-3 (25OHD(3)) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean ( +/- SD) 4.1 +/- 2.9 years). These vaules were compared with data obtained from a control group.Results: Adjusted mean BMD values were lower in the patient group than in controls (P < 0.05). However, there was no difference between BMD values of ambulant acid non-ambulant patients, The Ca and P levels of the patient group were significantly higher than those of controls (P < 0.05).Conclusions: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.