BASIC CONCEPTS IN CARDIOLOGY The Oxygen Free Radical System: Potential Mediator of Myocardial Injury
BASIC CONCEPTS IN CARDIOLOGY The Oxygen Free Radical System: Potential Mediator of Myocardial Injury
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发表时间：
2010
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通讯作者：
Arnold M. Katz;Billy Hammond;Michael;Hess
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作者：
Arnold M. Katz;Billy Hammond;Michael;Hess
氧的连续单价还原产生非常活泼的中间产物，包括超氧阴离子自由基、过氧化氢和自由羟基自由基。正常情况下，这些氧中间产物的组织浓度受到严重限制;然而，如果产生的氧自由基超过组织消除它们的能力，它们可能会造成严重损害。本文综述了缺血/再灌注损伤动物模型中自由基产生的生物化学和可能来源。近年来，关于氧代谢中间产物在生理和病理条件下的参与有了许多新的信息。氧的连续单价还原产生非常活泼的中间产物，如超氧阴离子自由基、过氧化氢和自由羟基自由基。这些氧中间产物在正常组织中的积累受到超氧化物歧化酶、过氧化氢酶和过氧化物酶家族的限制，这些酶作为细胞内防御机制对抗氧自由基的过度产生。如果产生的氧自由基超过了组织消除它们的能力，它们可能会造成严重的损害。例如，氧自由基已被证明可以杀死细菌、溶解细胞、引发细胞膜的脂质过氧化和破坏酶。氧自由基破坏多种细胞成分的能力导致了这样的建议，
The sequential univalent reduction of oxygen gives rise to very reactive intermediate products including super oxide anion radical, hydrogen peroxide and free hy droxyl radicals. Normally, the tissue concentration of these intermediate products of oxygen is severely limited; however, if oxygen free radicals are produced in excess of the capacity of the tissues to eliminate them, they may cause serious damage. The biochemistry and possible sources of free radical generation in animal models of ischemic/reperfusion injury are reviewed. The ability of In recent years there has been much new information con cerning the involvement of intermediate products of oxygen metabolism in both physiologic and pathologic conditions. The sequential univalent reduction of oxygen gives rise to very reactive intermediate products such as the superoxide anion radical, hydrogen peroxide and the free hydroxyl rad ical. The accumulation of these intermediate products of oxygen in normal tissues is limited by a family of superoxide dismutases, catalases and peroxidases, which serve as an intracellular defense mechanism against the overproduction of oxygen free radicals. If oxygen free radicals are produced in excess of the capacity of the tissue to eliminate them, they may cause serious damage. For example, oxygen free radicals have been shown to kill bacteria, lyse cells, initiate lipid peroxidation of cell membranes and inactivate en zymes. The ability of oxygen free radicals to damage a wide variety of cellular components has led to the suggestion that