EXPRESSION OF FGF AND FGF RECEPTOR GENES IN HUMAN BREAST-CANCER
EXPRESSION OF FGF AND FGF RECEPTOR GENES IN HUMAN BREAST-CANCER
复制标题
DOI：
10.1002/ijc.2910610205
复制
发表时间：
1995-04-10
影响因子：
6.4
通讯作者：
DELAPEYRIERE, O
中科院分区：
文献类型：
--
作者：
PENAULTLLORCA, F;BERTUCCI, F;DELAPEYRIERE, O
FGF 生长因子家族参与多种生物过程，可能在肿瘤发生中发挥重要作用。我们使用 RT-PCR 和 Northern blot 分析，研究了 10 个肿瘤细胞系和 103 个乳腺肿瘤样本中 9 个特征性 FGF 基因中的 8 个以及 4 个已知 FGF 受体基因的各自表达。 FGF1和FGF2几乎在所有样品中都有表达，而FGF5、FGF6、FGF7和FGF9的表达受到更多限制。 FGFR1、FGFR2 和 FGFR4 分别在 22%、4% 和 32% 的肿瘤中高水平表达。未检测到 FGFR3 表达。编码具有 2 个免疫球蛋白样结构域的 FGFR1 同工型的转录本是最常见的。 (C) 1995 Wiley-Liss, Inc.
The family of FGF growth factors is involved in several biological processes and might play an important role in tumorigenesis. We have studied the respective expression of 8 of the 9 characterized FGF genes, and of the 4 known FGF receptor genes, in a panel of 10 tumor-cell lines and 103 breast-tumor samples, using RT-PCR and Northern-blot analyses. FGF1 and FGF2 were expressed in almost all samples, while expression of FGF5, FGF6, FGF7 and FGF9 was more restricted. FGFR1, FGFR2 and FGFR4 were expressed at high levels in respectively 22%, 4% and 32% of tumors. FGFR3 expression was not detected. The transcript encoding an FGFR1 isoform with 2 immunoglobulin-like domains was the most prevalent. (C) 1995 Wiley-Liss, Inc.