The catabolism of alpha1-fetoprotein and albumin in rats bearing Morris hepatoma 7777.
The catabolism of alpha1-fetoprotein and albumin in rats bearing Morris hepatoma 7777.
复制标题
莫里斯肝癌 7777 大鼠中甲胎蛋白和白蛋白的分解代谢。
作者：
S. Sell
纯化的放射性标记α1F(α1F)(1 1天)和白蛋白(2 2天)在血清平均浓度为0.054微克/毫升的正常大鼠和平均血清浓度为46微克/毫升的莫里斯肝癌(α777)大鼠中的分解代谢率相同，几乎是正常的1 000倍。α1F(1.3天)和白蛋白(3.2天)的分解代谢率在大肿瘤大鼠(血清α1F浓度，7800微克/毫升)死亡前被发现。荷瘤动物血清α-1F浓度升高不能用分解代谢降低来解释，而是由于肝癌组织快速合成所致。由于1天的快速t1/2，血清α1F浓度准确地反映了大鼠体内产生α1F的肿瘤的存在和状况。
The rate of catabolism of purified radiolabeled α1-fetoprotein (α1F) ( t ½, 1.1 days) and albumin ( t ½, 2.2 days) is the same in normal rats with a mean α1F serum concentration of 0.054 µg/ml and in rats bearing 2- to 5-g tumors of Morris hepatoma 7777 that have a mean serum concentration of 46 µg/ml, almost 1000 times normal. A decreased rate of catabolism of both α1F (1.3 days) and albumin (3.2 days) is found in rats with large tumors (serum α1F concentrations, 7800 µg/ml) just prior to death. The rising serum α1F concentration in hepatoma-bearing animals cannot be explained by decreased catabolism but is due to rapid synthesis by the hepatoma tissue. Because of the fast t 1/2 of 1 day, the serum α1F concentration accurately reflects the presence and condition of α1F-producing tumors in the rat.