Growth patterns and metastatic behavior of human tumors growing in athymic mice.
Growth patterns and metastatic behavior of human tumors growing in athymic mice.
复制标题
在无胸腺小鼠中生长的人类肿瘤的生长模式和转移行为。
作者：
A. Kyriazis;Linda Dipersio;Gabriel Michael;Amadeo J. Pesce;J. Stinnett;Surgery ¡j D S
本文研究了裸鼠体内生长的人肿瘤的生长特点和转移行为。将人肿瘤细胞株Hep-2(喉癌或喉癌)和SW480(结肠癌)移植到BALB/c裸鼠体内。肿瘤细胞(1×10(6)和2×10(7))分别经皮下注射或皮下注射。或者IP。紧随S.C.注射肿瘤发展迅速，在2周内就能很容易地触及到，形成鳞状细胞瘤。肿瘤病灶周围有一层厚厚的纤维膜。患有S.C.的动物。移植几乎没有受到不断增长的肿瘤的影响。在第34天(HEP-2)和第62天(SW480)处死他们时，大部分肿瘤已经坏死。观察淋巴管、神经周围和血管周围淋巴间隙的包膜渗入和侵犯。在存活长达6个月的动物中，发现区域淋巴转移。在IP之后。移植后，肿瘤在腹膜腔内广泛扩散，侵犯腹内脏器，并转移至纵隔淋巴结和肺。26只动物中有15只(60%)发生了转移。IP的坏死。生长的肿瘤很小。这组动物中的所有动物都死于肿瘤生长。
The growth characteristics and metastatic behavior of human tumors growing in athymic nude mice were studied. Human tumor cell lines HEp-2 (carcinoma or larynx) and SW480 (colon carcinoma) were transplanted into athymic nude mice of BALB/c origin. Tumor cells (1 x 10(6) and 2 x 10(7)) were given either s.c. or i.p. Following s.c. injection tumors developed rapidly to become easily palpable with 2 weeks forming a s.c. tumor focus surrounded by a thick fibrous capsule. Animals with s.c. transplants were little affected by the growing tumor. At the time they were sacrificed at Day 34 (HEp-2) and 62 (SW480), a large part of the tumor was necrotic. Capsular infiltration and invasion of lymphatic vessels and perineural and perivascular lymphatic spaces were observed. Metastases to regional lymph nodes were seen in animals kept alive for up to 6 months. Following i.p. transplantation, tumors spread widely in the peritoneal cavity, invaded intraabdominal organs, and metastasized to mediastinal lymph nodes and lungs. Fifteen of 26 animals (60%) developed metastases. Necrosis of the i.p. growing tumors was minimal. All animals in this group died as a result of tumor growth.