Extracellular calcium acts as a "third messenger" to regulate enzyme and alkaline secretion.
Extracellular calcium acts as a "third messenger" to regulate enzyme and alkaline secretion.
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DOI：
10.1083/jcb.200310145
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发表时间：
2004-07-05
期刊：
影响因子：
--
通讯作者：
Curci S
中科院分区：
文献类型：
--
作者：
Caroppo R;Gerbino A;Fistetto G;Colella M;Debellis L;Hofer AM;Curci S
一般认为，Ca2+动员激动剂刺激的功能后果仅来自细胞内Ca2+的第二信使作用，作用于细胞内的靶标。然而，在Ca2+信号事件中，Ca2+进出细胞，不仅引起细胞内Ca2+的变化，而且引起局部细胞外Ca2+的变化。许多细胞类型拥有细胞外Ca2+“传感器”的事实提出了一个问题，即这些外部[Ca2+]的动态变化是否可能服务于某种信使功能。我们发现，在完整的胃粘膜中，细胞外[Ca2+]的变化是由碳水化合物诱导的细胞内[Ca2+]的增加引起的，这是引起碱性分泌和胃蛋白酶原分泌的充分和必要的，独立于细胞内[Ca2+]的变化。这些发现表明，细胞外Ca2+可以作为“第三信使”通过Ca2+传感器(s)来调节组织功能的特定亚群以前被认为是在细胞内Ca2+的直接控制下。
It is generally assumed that the functional consequences of stimulation with Ca2+-mobilizing agonists are derived exclusively from the second messenger action of intracellular Ca2+, acting on targets inside the cells. However, during Ca2+ signaling events, Ca2+ moves in and out of the cell, causing changes not only in intracellular Ca2+, but also in local extracellular Ca2+. The fact that numerous cell types possess an extracellular Ca2+ “sensor” raises the question of whether these dynamic changes in external [Ca2+] may serve some sort of messenger function. We found that in intact gastric mucosa, the changes in extracellular [Ca2+] secondary to carbachol-induced increases in intracellular [Ca2+] were sufficient and necessary to elicit alkaline secretion and pepsinogen secretion, independent of intracellular [Ca2+] changes. These findings suggest that extracellular Ca2+ can act as a “third messenger” via Ca2+ sensor(s) to regulate specific subsets of tissue function previously assumed to be under the direct control of intracellular Ca2+.
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影响因子：
4.5
作者：
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通讯作者：
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作者：
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通讯作者：
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