The Use of Athymic Nude Mice for the Study of Human Keloids
The Use of Athymic Nude Mice for the Study of Human Keloids
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DOI：
10.3181/00379727-179-rc3
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发表时间：
1985-09
影响因子：
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通讯作者：
M. Shetlar;C. L. Shetlar;L. Hendricks;C. Kischer
中科院分区：
文献类型：
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作者：
M. Shetlar;C. L. Shetlar;L. Hendricks;C. Kischer
摘要将瘢痕疙瘩组织植入胸腺裸鼠体内，为研究人类瘢痕疙瘩和增生性瘢痕建立实验动物模型。未经处理的瘢痕疙瘩组织在胸腺小鼠植入后至少60天内基本保持相同的形态模式和糖胺聚糖分布。以同样方式植入的正常人皮肤维持正常，糖胺聚糖的分布和形态特征没有变化。我们认为该模型可以用于瘢痕疙瘩和增生性瘢痕的基础研究，因为它可以在控制条件下研究形态学，生化和治疗的相互关系。
Abstract Keloid tissue has been implanted in the athymic nude mouse in order to develop an experimental animal model for the study of human keloids and hypertrophic scars. Untreated keloid tissues maintained essentially the same morphological patterns and glycosaminoglycan distributions for at least 60 days after implantation in the athymic mice. Normal human skin implanted in the same way was maintained without change in glycosaminoglycan distribution or morphologic characteristics. We suggest that this model may be useful for basic research of keloids and hypertrophic scars in that it will allow studies of morphologic, biochemical and therapeutic interrelationships under controlled Conditions.